Thermodynamic dissociation constants of risedronate using spectrophotometric and potentiometric pH-titration
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The dissociation constants of the cytostatic bosutinib by nonlinear least-squares regression of multiwavelength spectrophotometric and potentiometric pH-titration data.
Potentiometric and spectrophotometric pH-titration of the multiprotic cytostatics bosutinib for dissociation constants determination were compared. Bosutinib treats patients with positive chronic myeloid leukemia. Bosutinib exhibits four protonatable sites in a pH range from 2 to 11, where two pK are well separated (ΔpK>3), while the other two are near dissociation constants. In the neutral med...
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ژورنال
عنوان ژورنال: Open Chemistry
سال: 2012
ISSN: 2391-5420
DOI: 10.2478/s11532-011-0150-3